Itching at the roots of the thighs in men requires first a clear diagnosis. The most common type of ringworm in the thigh root area is tinea cruris, which is a well-defined erythematous rash that can be accompanied by flaking and blistering. The treatment for ringworm can be topical antifungal medications like terbinafine cream, naftifine ketoconazole cream, and luliconazole cream, which are applied for at least another week after the rash subsides. In addition to ringworm, itchy thigh roots are more commonly associated with eczema, which is caused by local sweating irritation, friction, etc. The boundaries of the erythema are not clear, and there may be no obvious rash. Eczema can be treated topically with topical application of furnace glycerin lotion, which has anti-inflammatory, astringent, and anti-itch properties, or topical application of dinaide cream if there is an obvious rash, which also has a better anti-inflammatory and anti-itch effect.