Uremia can be categorized into central and renal urolithiasis. In case of central urolithiasis, it can be treated with oral desmopressin acetate, and in case of renal urolithiasis, it can be treated with oral hydrochlorothiazide and chlorosulfonylurea. Uremia is generally defined as a disease characterized by severe or relative deficiency of arginine pressin, or renal insensitivity to arginine pressin, which leads to dysfunction of tubular reabsorption of water, polyuria, severe thirst, and polydipsia with decreased urine specific gravity. If there is a relative or absolute deficiency of argipressin, it is called central urosepsis, which is generally due to a hereditary or acquired cause of insufficient secretion of argipressin from the hypothalamus. It can be treated with oral desmopressin acetate, which can effectively improve the symptoms, especially in controlling the number of nighttime urination and water intake. In the case of nephrourette, antidiuretic treatment with hydrochlorothiazide and chlorosulfopropylurea can help to increase tubular reabsorption and thus reduce urine output. However, it should be noted that desmopressin acetate, may cause water intoxication, while hydrochlorothiazide may cause hypokalemia and hyperuricemia, and chloropropamide may trigger severe hypoglycemia and water intoxication. Therefore these drugs are contraindicated in patients with water intoxication. If you have uremic syndrome, it is recommended to seek medical attention in time, follow the doctor’s instructions for examination and treatment, do not take medication without authorization, in order to avoid medication is not appropriate, damage to the body.