Parkinson’s disease (PD) is a progressive neurodegenerative disease, the exact cause of the disease is unknown, there is no effective prevention methods, the disease is generally progressive aggravation, the disability rate is high, seriously affecting the quality of life of patients, because some patients do not know enough about this type of disease, can not be timely consultation, and The loss of work and living ability or even long-term paralysis in bed adds a heavy burden to the family, and the disease is often complicated by pulmonary infections, urinary tract infections and bed sores in the later stages of the disease, resulting in death. Therefore, the scientific and standardized treatment of Parkinson’s disease patients and effective reduction of disability and death rate is an urgent task, patients get scientific, standardized and effective treatment can not only improve the quality of survival, restore normal working ability and prolong life, but also reduce the burden of care and economic burden of patients’ families. I. Clinical manifestations: (1) Tremor The first symptom of about 60-75% of patients is tremor, characterized by slow rhythmic resting tremor, 4-6 times/second, mostly starting from one upper limb, gradually developing to the ipsilateral lower limb, and then involving the contralateral upper and lower limbs. (2) Muscle stiffness Increased tension of the affected muscles, inflexible joint movement, early forearm and finger muscle stiffness, manifested as distorted writing, smaller and smaller words, i.e. “writing hypermetropia”, the patient’s facial muscles are straight, lack of normal expression, dull face, called “mask face The patient’s facial muscles are tense, lacking normal expressions, with a dull face, called “mask face. (3) Delayed movement Slow, clumsy, uncoordinated activities, unable to complete some fine movements, such as tying shoelaces, buttons, etc. In severe cases, there are difficulties in standing, walking and turning over. (4) Abnormal posture The head and trunk are tilted forward when standing, and both knees are bent in a forward posture. When walking, it is difficult to start, and the feet seem to be stuck to the ground, which is called “stagnant gait” or “frozen gait”. After opening the gait, the faster you walk, the faster you rush forward at a small pace, i.e. “panic gait”, unable to turn or stop in time, slow walking pace, small stride length, lower limbs dragging, difficulty in turning and turning the neck, lack of joint movements such as swinging the upper limbs back and forth. (5) Other manifestations Combined with phytokinetic disorders such as intractable constipation, urinary urgency, urinary incontinence, sexual dysfunction, increased secretion of sweat or sebaceous glands, and depression, anxiety and other psychiatric symptoms. (1) Treatment principles: early medication, individualized medication, appropriate dosage, and combined medication. (2) Commonly used drugs: Methocarbamol, Benadryl, Amantadine, Tamsulosin, Antan, Slegiline, etc. Surgery: There is a general consensus among domestic and foreign neuroscience experts that surgery is the ultimate and only option for Parkinson’s disease treatment. (1) Indications: For primary Parkinson’s disease with dysfunction and effective dopamine replacement therapy, patients should consider surgery after systematic drug treatment, but with reduced efficacy, significantly shorter drug maintenance time, involuntary abnormal limb activity after taking drugs, and “on-off” phenomenon. (2) Surgical methods: ① Deep brain nucleus cytodissection Using image stereotactic technology and micro-electrode guided neurophysiological technology for anatomical and kinetic localization of the brain nucleus respectively, followed by radiofrequency electrode destruction of specific nucleus to reduce the abnormally increased excitability of the nucleus, thus treating tremor, tonicity and movement disorders in Parkinson’s disease patients, with advanced technology, accurate localization, significant efficacy and lasting effect. ②Brain pacemaker treatment The above-mentioned stereotactic method is used to implant stimulating electrodes into the inner nucleus accumbens and apply electrical stimulation to suppress the electrical excitation of neurons around the target, without destroying the nerve cells at the target, but by adjusting the stimulation parameters to achieve the effect of treating various symptoms of Parkinson’s disease, which has the advantages of reversibility and adjustability. Surgical treatment can greatly improve the clinical symptoms and restore the patient’s ability to live.