Chronic atrophic gastritis with erosion type C2 refers to moderate atrophy of the gastric mucosa, i.e., one-third to two-thirds of the intrinsic glands of the gastric mucosa are atrophied, accompanied by erosion of the gastric mucosa. Chronic atrophic gastritis with erosion type C2, the atrophic parts are mostly seen in the gastric sinus, gastric angle, lower gastric body gastric curvature, the overall degree of atrophy has basically exceeded the gastric angle, but the cardia at the mucous membrane has not yet been involved. Chronic atrophic gastritis with erosion C2 type is mostly due to the infection of Helicobacter pylori bacteria failed to timely examination and treatment, after a long period of prolonged delay, may also be associated with autoimmune disorders, bile reflux, severe alcoholism, long-term stimulating diet and a series of non-steroidal anti-inflammatory drugs as a representative of the long-term damage to a series of chemical drugs and other factors. Patients with chronic atrophic gastritis with the presence of Helicobacter pylori should be treated with anti-Helicobacter pylori quadruple therapy program, along with magnesium alumina carbonate, Rebapatide and other gastric mucosa protectants. The above drugs should be used under the guidance of professional physicians. Patients with atrophic gastritis should have a reasonable diet, regular diet, do not eat spicy and stimulating food, quit smoking and alcohol, and regular review, according to the doctor’s guidance of medication.