A half empty toenail may be due to nail malnutrition caused by gray nail or other inflammation of the nail bed of the nail plate. If the fungal infection enters the deeper nail plate, the nail bed develops gray nails and the nails become empty. It is recommended to use oral medication to control the deep fungal infection, the effect of topical medication are not too good, the commonly used oral drugs are itraconazole, terbinafine tablets, etc., to standardize the adequate amount of medication, in order to ultimately control the fungal infection. Of course, other common fungal infections, nail plate, nail bed can also lead to empty nails, this situation can be used externally amoxicillin and other anti-inflammatory drugs or external human epidermal growth factor gel, which can help the nail plate and nail bed as soon as possible to restore function. Toenail empty half of the recommended timely visit to the hospital, clear cause of the disease in a timely manner under the guidance of the doctor symptomatic treatment, do not self-medication, usually pay attention to keep the feet ventilated and breathable.