Open neural tube defects high risk, can check the ordinary non-invasive DNA, it is recommended that pregnant women at the same time improve the ultrasound examination to assist prenatal diagnosis. High risk of open neural tube defects is the result of Down’s syndrome screening, due to the low accuracy of the results of Down’s syndrome screening, the results can only be used as a reference, the patient can carry out ordinary non-invasive DNA examination, the accuracy rate is relatively high compared to Down’s syndrome screening, and once again to clarify the chromosomal and genetic conditions of the fetus, to rule out the existence of chromosomal abnormalities in the fetus. It should be noted that pregnant women also need to undergo further ultrasound examination at the same time, under the ultrasound systematic examination to clarify the presence of open neural tube defects in the fetus, to assist prenatal diagnosis, and timely termination of pregnancy, if necessary, to avoid adverse pregnancy outcomes. If the pregnant woman has abnormal results, she should undergo further examination as soon as possible under the guidance of a specialized physician, so as to avoid delaying the condition and leading to adverse consequences.