Sudden crying in sleep is usually caused by the stimulation of the surrounding environment or systemic diseases such as electrolyte disorders, infections, skin allergies, mosquito bites, etc. Therefore, we need to deal with the symptoms. First of all, the infant cranial nerve development is not mature, peripheral nerve conditioned reflexes are not perfect, the external environment such as bright light, noise, mosquitoes and other bad stimulation can lead to sudden crying, this situation needs to pay attention to the surrounding environment regulation, pay attention to mosquitoes and insects can be improved. In addition, their own digestive system diseases such as sudden onset of intestinal infarction, colic, pain and crying, accompanied by abdominal distension, nausea and vomiting, etc., need to seek urgent medical attention, serious cases need to perform surgical treatment. Again, hypocalcemia caused by vitamin D and calcium deficiency in newborns is also caused, generally accompanied by malnutrition, hair loss, night sweats and other manifestations, it is recommended to perform vitamin D and calcium measurement to determine the cause. If the deficiency can be treated by vitamin D and calcium supplementation. In addition, neurological diseases can also be caused, such as petit mal seizures, with a previous history of related diseases, it is recommended to perform cranial CT and electroencephalography for treatment. In conclusion, if the symptoms are recurrent, it is recommended to visit the hospital for examination and treatment, including cranial CT, electrolytes, EEG and other tests to clarify the cause and prevent the complication of other systemic diseases.