Lithium carbonate is mainly used for the treatment of depression, and sodium valproate is mainly used for the treatment of epilepsy. Lithium carbonate should not be used during pregnancy or breastfeeding, and sodium valproate should be used cautiously in girls under the guidance of a medical professional. The two drugs have different indications and ages, so it is not possible to say clearly which drug is better for girls. Lithium carbonate and sodium valproate both have a certain sedative effect, lithium carbonate can stabilize mood, commonly used in the treatment of depression, mania and so on. Sodium valproate is a broad-spectrum antiepileptic drug, which can be used to treat various kinds of epilepsy such as petit mal seizures and limited seizures, and it can also be used to treat schizophrenia and so on. The medication used varies in girls with different morbidities. Lithium carbonate is contraindicated in girls during the first trimester of pregnancy, and breastfeeding should be discontinued if the drug is used during breastfeeding. Sodium valproate may only be used in girls, female adolescents, pregnant and breastfeeding women when other medications have failed or are not tolerated. Which specific drug for girls is related to the condition, age group and so on, can not clearly say which one is good, should be used reasonably under the guidance of the doctor. Adverse reactions to lithium carbonate include nausea, vomiting, loss of appetite. It is forbidden for those who are allergic to the drug, patients with severe kidney disease, etc. Children under 12 years old should not use the drug. Adverse reactions of sodium valproate include diarrhea, dyspepsia, etc. It is contraindicated for those who are allergic to the drug and those with severe liver impairment. The use of this drug together with medications such as aspirin may increase the risk of bleeding. If you need to use these two drugs, you should use them wisely under the guidance of your doctor.