In daily life, people should have seen some patients with skull defects, they seem to be no different from normal people, and it is precisely for this reason that many people feel that there is no need to pay attention to skull defects, but is it really true? Of course not, cranial defects have a great impact on the health of the organism, the defective parts usually do not grow back on their own, and over time can cause more damage to the patient. Cranial defect will destroy the stability of the intracranial environment, cerebrospinal fluid circulation and cerebral blood circulation will be affected, but also hurt the nerve function, which leads to a series of cranial defect syndrome, the specific performance can be headache and dizziness, limb muscle strength loss, mental inattentiveness and so on, serious patients can be combined with cerebral bulging, penetrating deformity and other problems, threatening the health of the lives of the patients. Cranial defect is a big problem, patients should not take it lightly, active response and treatment is the key. Clinical treatment of cranial defects is mainly to take cranial bone repair surgery, which is a more classic surgery, as early as thousands of years ago, the prototype of this surgery, the development of technology has been quite mature, patients can rest assured that the surgery. When is the best time to have cranial repair? The optimal time for cranial repair is 3-6 months after the flap procedure, but that doesn’t mean that it can’t be done after that time. The specific situation should be evaluated by a specialist before scheduling the surgery. Cranial bone repair is of great significance. In addition to choosing the right time, the choice of repair material should also be careful. At present, there are many materials for cranial bone repair surgery, but after clinical comparison, the polyether ether ketone peek material that we are using now is more advantageous. The properties of the peek material are very close to those of the autologous cranial bone, and there will be no adverse reaction after the surgery, and the effect is also very natural and beautiful. And we also continue to improve and innovate the technology, and introduce the concept of cosmetic surgery, comprehensive development of PEEK cranial bone repair and plastic surgery, clinical results are good.