Monkeypox is a zoonotic viral disease. Humans are infected with monkeypox, mainly through being bitten by an infected animal or through direct contact with blood, body fluids, or skin lesions of an infected animal; it is usually transmitted from animal to human, and human-to-human transmission of monkeypox can also occur. Monkeypox was first discovered in 1958 in a laboratory in Copenhagen, Denmark, and was first found in humans in 1970 in west-central African countries. Since then, there have been many reports of related cases in Africa, and the disease of monkeypox is relatively mild, with a case-fatality rate of 1% to 10%. In 2003, monkeypox cases appeared in many places in the United States, and it was hypothesized that it might be related to the sale of African prairie dogs and rats by local pet dealers.2022 Since May, many cases of monkeypox have been reported in the United Kingdom and the United States. At present, there is no specific treatment for monkeypox. Wildlife workers should be properly sterilized and protected, and should avoid contact with wildlife in their daily lives.