The 100-year-old recently noisy day and night may be Alzheimer’s disease, brain atrophy, etc.. Alzheimer’s disease is a kind of insidious onset, progressive development of the nervous system degenerative diseases, mainly manifested as cognitive function decline, lethargy and behavioral disorders such as day and night noisy, etc.; family members should be accompanied by a lot of people, can be under the guidance of the doctor to take drugs to improve cognitive function. With age, the brain can atrophy to a certain extent, and patients with brain atrophy can show intelligence loss and personality change, etc., and should require special care to prevent the patient from getting lost; ergot alkaloid preparations can be taken under the guidance of a doctor. If the 100-year-old man has been noisy day and night recently, he should consult a doctor in time to find out the cause so as not to delay his condition.