Tg-ab is also known as anti-thyroglobulin antibody; high Tg-ab can be seen in normal people, but also in Hashimoto’s thyroiditis, hyperthyroidism and thyroid cancer.
In some normal people, especially women, the anti-TG positivity rate increases with age, and the detection rate of women over 40 years old can reach 18%.
90% to 95% of Hashimoto’s thyroiditis may have increased serum Tg-ab. Thyroglobulin (TG) is a glycoprotein synthesized by thyroid follicular cells, and Tg-ab has a complement-fixing and cytotoxic effect, and is involved in thyroid cell damage.
Antithyroglobulin antibody positivity can be seen in 52% to 58% of patients with hyperthyroidism and 35% of patients with thyroid cancer.
In addition, Tg-ab positivity can be seen in myasthenia gravis, liver disease, rheumatic vascular disease, and diabetes mellitus.
Patients should not rely on a single test result to determine a particular disease, and are still advised to visit a hospital and cooperate with their physician for further treatment.