Supplemental Jarrow, also known as estradiol valerate tablets. Side effects of estradiol valerate tablets include breast swelling, nausea, headache, and irregular vaginal bleeding. The danger of estradiol valerate tablets is that their use increases the risk of blood clots, gallbladder disease, dementia, and tumors. Estradiol valerate tablets are estrogenic drugs. They are mainly used to treat estrogen deficiency associated with natural or artificial menopause. During use, adverse reactions such as breast swelling, stomach upset, nausea, headache, changes in weight and libido, and irregular vaginal bleeding may occur. Before using estradiol valerate tablets for estrogen supplementation, patients need to be evaluated to rule out contraindications to its use: e.g., women who are pregnant and breastfeeding, unexplained vaginal bleeding, breast cancer or malignant tumors affected by sex hormones, severe liver disease, thromboembolic disorders, and allergy to the drug. Patients should take estradiol valerate tablets under medical supervision and seek medical advice if adverse reactions occur.