Long-term use of Corkscrew may have adverse consequences such as skin sensitization, formation of dependence and rectal irritation. 1. Skin allergy: Keserol needs to be inserted into the anus, and long-term contact with perianal skin may cause allergic reactions, manifested as anal itching, burning sensation, rash and other discomforts. 2. Formation of dependence: Keserol is the use of glycerin, high concentration, high osmotic effect of softening feces, stimulate the intestinal wall reflex to produce defecation response, can temporarily relieve the symptoms of difficult stool. The long-term use of Keselen will form a dependence. 3. Irritation of the rectum: long-term use of Keserol may irritate the rectum, causing irreversible enteric nerve damage, with constipation and diarrhea occurring alternately. It is recommended that patients use Keserol under the guidance of a medical professional, and frequent use is not recommended.