Multinucleated giant cells are a relatively common type of cell in pathology, suggesting that the organism is in a pathological state, which may be caused by tumors, chronic inflammation and so on. 1. Chronic inflammation: it is mainly formed by macrophages surrounding metabolic products or external foreign bodies. It is mainly seen in the chronic granulomatous inflammation caused by foreign body stimulation, but generally it will not be cancerous, and only belongs to the granulomatous repair of ulcers, accompanied by the phenomenon of phagocytosis of histiocytes. 2. Tumor: multinucleated giant cells can also be seen in patients with giant cell tumor of bone, which is a kind of common bone tumor mainly characterized by osteolysis. If multinucleated giant cells are detected in the pathology of osteoblastoma, which suggests the tumorigenic mutation of osteoclasts, timely surgical resection of the tumor is needed, and according to the specific circumstances, the scope of surgical resection and whether to carry out radiotherapy or chemotherapy should be decided. If the patient pathologically found multinucleated giant cells need to promptly identify the cause of the disease, under the guidance of the doctor for treatment.