Excessive supplementation of progesterone in the early stages of a pregnant woman’s pregnancy can have an effect on the fetus. In the clinical supplementation of progesterone drugs are mainly progesterone drugs. Although progesterone belongs to the birth control drugs, but taking too much, long-term large doses of serious can cause fetal malformation lesions. In particular, it can cause fetal spine, limbs, anus and other parts of the body, the likelihood of malformation will increase significantly. Due to fetal malformations will have a certain impact on the pregnant woman’s psychological as well as physical. Therefore, for patients taking progesterone for treatment need to have their blood tested for progesterone on a regular basis, depending on the patient’s specific condition, in the event of preeclampsia or miscarriage. Under the guidance of obstetricians and gynecologists, the use of drugs based on the condition of the patient and the results of the progesterone test can minimize the risk.