Platelet count 380×10^9/L belongs to platelet elevation, if it is physiological elevation, it is not serious, if it is primary elevation such as chronic granulocytic leukemia, it is serious and needs chemotherapy, if it is caused by acute and chronic inflammation, blood loss, etc., then it is more serious, and it needs to actively improve the primary disease. 1. Physiological elevation: the normal reference range is (100~300)×10^9/L. Increased platelet counts can occur in the middle and late stages of pregnancy and after menstruation, which is a normal physiological phenomenon, and it does not matter if it is not accompanied by diseases or discomfort. 2. Primary increase: common in myelodysplastic syndromes, primary thrombocythemia, chronic granulocytic leukemia, etc. Generally more serious, need to use cytarabine, imatinib and other drugs according to the specific cause of the disease to improve the prognosis. 3. Reactive increase: commonly secondary to acute and chronic inflammation, acute blood loss, hemolysis, etc., generally more serious, need to clarify the specific etiology, and actively correct the primary disease can improve the platelet count, such as to be levofloxacin anti-infection. Therefore, platelets 380 × 10 ^ 9 / L belongs to thrombocytosis, but also need to be combined with other indicators, specific analysis of the cause of the disease, under the guidance of the physician active treatment, to avoid delays in the condition.