The initial dose of metformin hydrochloride tablets is usually 0.25 grams taken once, 2-3 times a day, and the dose can be gradually increased according to the patient’s blood glucose situation until the satisfactory effect of sugar reduction is achieved. The general daily maintenance dose can reach 1-1.5 grams, at most not more than 2 grams per day, taken at the best of three meals, so as to reduce the adverse effects of gastrointestinal function. The most common adverse reactions of Metformin Hydrochloride tablets in the process of use are reactions of gastrointestinal function, such as diarrhea and nausea.