Entecavir can be used together with other drugs. Entecavir is mainly a medicine for hepatitis B, which can inhibit hepatitis B virus replication, and entecavir is more effective in inhibiting hepatitis B virus replication. However, the risk of drug resistance can also occur when entecavir is used. If resistance occurs, it can be switched to tenofovir, or combined with tenofovir. Entecavir can also be combined with interferon for antiviral therapy to improve serological conversion. Entecavir can also be used in combination with hepatoprotective drugs because some patients with hepatitis B will have abnormal liver function and need hepatoprotective therapy, so they need a combination of antiviral and hepatoprotective drugs, and can be treated with entecavir in combination with hepatoprotective drugs. Entecavir can also be combined with anti-cancer drugs because hepatitis B is a high incidence of liver cancer, and sometimes it can be combined with entecavir when anti-cancer treatment is needed.