Esophageal cancer is esophageal cancer, mediastinal lymph node metastasis after esophageal cancer surgery suggests that the cancer has recurrence and metastasis, and the prognosis of the disease can be improved through comprehensive treatment such as radiotherapy and targeted therapy. After recurrence and metastasis of esophageal cancer, patients need to be actively treated, and radiotherapy and targeted therapy can be used to shrink the tumor lesions, inhibit the growth of tumor cells, improve the quality of life of patients, prolong the survival time of patients, and improve the prognosis of the disease. The chemotherapy drugs that patients can choose include cytarabine, fluorouracil, paclitaxel, cyclophosphamide, cisplatin and so on; targeted drugs include sorafenib, trastuzumab and so on. The specific treatment choice of drugs need to be based on individualized strict compliance with the doctor’s instructions, such as the emergence of any adverse reactions such as headache, anemia, etc. promptly consult a doctor, drug allergy is prohibited.