The right lower abdomen hurts when pressed but not when pressed may be caused by chronic appendicitis, Crohn’s disease, intestinal tuberculosis and so on. 1. Chronic appendicitis: right lower abdominal pressure and pain without pressing. Most likely appendicitis, especially chronic appendicitis. Typical acute appendicitis is diagnosed on the basis of metastatic right lower abdominal pain and right lower abdominal pressure on examination. However, some chronic appendicitis, usually no obvious symptoms of abdominal pain, only pressure on the right lower abdomen when pressure pain. 2. Crohn’s disease: it is a chronic non-specific inflammatory bowel disease, mainly manifested as intermittent pain around the umbilicus or the right lower abdomen, but also may manifest as diarrhea, intestinal obstruction, fever, malnutrition, weight loss and other symptoms. It can also be manifested as pain in the right lower abdomen when pressed, but not pressed without pain. 3. Intestinal tuberculosis: it is a chronic specific infection caused by Mycobacterium tuberculosis invading the intestinal tissues, mainly manifested as persistent hidden pain in the right lower abdomen or around the umbilicus, which may be accompanied by low-grade fever, malaise, night sweating (abnormal sweating after going to sleep, and sweating stops after waking up), lumps in the right lower abdomen, diarrhea or constipation, etc. It may also be manifested as pain in right lower abdomen without pressing, nutrition, and weight loss. It can also manifest as pain in the right lower abdomen when pressed without pain when pressed. There are many other causes of right lower abdominal pain without pressing, which should be taken seriously, timely consultation, identify the cause of the disease, and follow the doctor’s instructions for further treatment or therapy.