Zinc in seminal plasma is mainly produced by the prostate gland and is an indicator for the evaluation of the secretory function of the prostate. It can be used to assess the status of prostate damage in patients with prostatitis. A decrease in seminal plasma zinc levels indicates that the prostate may be substantially damaged and that its secretory function is significantly reduced. The lower the seminal plasma zinc level, the more severe the damage to the prostate is likely to be. Decreased seminal plasma zinc levels are often accompanied by a decrease in the enzymes that promote the liquefaction of semen, resulting in increased semen viscosity, prolonged liquefaction time, and decreased sperm motility and viability, which can affect male fertility to some extent. The amount of zinc in the seminal plasma and the ability of the prostate to resist infection are also related, and the prostate’s defense mechanism against inflammation decreases when the zinc content is lowered, as does its antibacterial ability. The antimicrobial factor (RAF) contained in the prostate fluid of normal people can kill pathogens that trigger urinary tract infections, and zinc is an important component of PAF in the prostate fluid. When zinc levels in prostatic fluid are reduced in patients with prostatitis, RAF activity will be significantly inhibited or lost. Seminal plasma zinc is involved in the antioxidant metabolism of the male reproductive system and maintains sperm viability. Zinc binds to proteins to protect sperm membranes and delay lipid oxidation of sperm cell membranes, thus maintaining the stability and permeability of the cell membrane structure and maintaining good sperm viability. Once seminal plasma is deficient in zinc, the content of seminal plasma superoxide dismutase decreases and oxygen radical production increases, reducing the ability of seminal plasma to resist oxidative damage. Reduced seminal plasma zinc content and weakened sperm antioxidant capacity can trigger decreased sperm viability, increased DNA damage rate and increased reactive oxygen species, all of which can affect male fertility to some extent. The synthesis of DNA polymerase, lactate dehydrogenase, RNA polymerase and other enzymes in the male body requires the participation of zinc, and these enzymes have important roles in cell metabolism and tissue respiration, so zinc deficiency will reduce the activity of the relevant enzymes and affect spermatogenesis, maturation and energy acquisition. The right amount of zinc is necessary for sperm production and maturation. Long-term smoking can lead to lower zinc concentrations in seminal plasma, and the more you smoke daily, the lower your seminal plasma zinc concentration. In men, prostate secretion gradually decreases with age, and seminal plasma zinc secretion begins to decrease, but due to the supplementation of exogenous zinc in food, the decrease in zinc content in semen is not significant in many senior men.