Large platelet ratio refers to the proportion of large platelets in the body to the total platelets in the body. A high large platelet ratio may be an overall decrease in platelets or an increase in large platelets, with common causes being physiological changes and pathological causes. First, physiological factors: 1, people after exercise or noon diet platelets will increase, after the normal metabolic activities can return to normal levels; 2, women before menstruation platelets can be reduced, in the first day of menstruation can be reduced by half, after the menstrual cycle can be elevated again. Second, pathological factors: 1, the overall reduction of platelets: common in aplastic anemia, radiation disease, hypersplenism, and immune thrombocytopenic purpura or idiopathic thrombocytopenic purpura; 2, increased large platelets: seen in primary thrombocytosis, characterized by bleeding tendencies and thrombosis, as the disease is often accompanied by repeated bleeding, so there will be an increase in platelets. High large platelet ratio has an important significance in the formation of white platelet plugs, release of platelet factors, promotion of coagulation and clot contraction, etc. Generally, it will not cause too much harm to the human body when the coagulation function is normal, and it is recommended to go to the hospital for further examination when this condition occurs.