Thickening and hardening of the skin on the hands may be related to conditions such as callus, tinea cruris, eczema, palmoplantar keratosis, etc. General treatment and medication are usually used. 1. Callus: generally, the hand is subjected to long-term mechanical stimulation as well as repeated friction, resulting in roughness and thickening of the skin in the area, or even the appearance of bulging performance. Generally do not need special treatment, also do not need special medication. Pay attention to wear loose shoes and socks on weekdays to reduce friction. 2. Ringworm: If the hands are infected by fungi, it will lead to small blisters on the hands, accompanied by obvious itching symptoms, with the passage of time, the skin in the area will be dry, peeling and hardening; you can apply bifonazole cream, miconazole cream and other medications, and if necessary, with oral itraconazole capsules. 3. Eczema: If there is eczema on the hands, it will lead to itchy skin rashes, and over time, the eczema area will be thickened and hardened. You can apply mometasone furoate, halometasone cream and other medications to treat the condition, and take oral loratadine tablets, cetirizine hydrochloride tablets and other medications if necessary. 4. Palmoplantar keratosis: these patients will appear local skin thickening, cracking and other phenomena, can be coated with retinoic acid cream, salicylic acid cream and other drugs. It is recommended that patients seek timely medical attention to clarify the cause of the disease, and then according to the cause of the disease strictly comply with the doctor’s prescription medication, do not self-medication.