Antihypertensive medications are required for life for people with high blood pressure. Taking antihypertensive drugs year-round may result in hazards such as elevated blood potassium, angioedema, and dry cough. 1. Elevated blood potassium: Angiotensin-converting enzyme inhibitors such as captopril and angiotensin II blockers such as telmisartan can have side effects such as elevated blood potassium when taken for a long time. 2. Decreased blood potassium: Thiazide diuretics, such as indapamide tablets, may have side effects such as decreased blood potassium with long-term use. 3. Angioedema: calcium antagonists such as nifedipine extended-release tablets may cause angioedema when taken for a long time. 4. Dry cough: Long-term use of angiotensin-converting enzyme inhibitors such as captopril may result in irritating dry cough. Those who cannot tolerate it may be replaced with angiotensin II blockers such as valsartan. Regular monitoring of blood pressure, electrolytes and liver function is recommended while taking antihypertensive drugs, and an individualized antihypertensive regimen should be given under the guidance of a physician. If there is any discomfort, consult the doctor in time and adjust the medication under the doctor’s guidance.