Perianal fissures need to be under the guidance of a doctor to choose the appropriate medication according to the primary cause of the treatment, common drugs include erythromycin ointment, Ma Yinglong musk hemorrhoidal cream, Dinaid cream and so on. 1. The perianal fissure caused by anal fissure can be used externally with erythromycin ointment, nitroglycerin ointment, etc. to play the role of anti-inflammatory and promote the healing of anal fissure. The latter may cause headache, nausea and other adverse reactions, and the use of contraindications such as recurrent headache, low blood pressure, allergic to nitric acid drugs and other people prohibited from use. 2. Hemorrhoids caused by perianal fissures can use potassium permanganate lotion for local cleaning, external use of Ma Yinglong musk hemorrhoid cream and other preventive treatment. 3. Perianal eczema caused by perianal fissures can be treated with topical Dinaid cream, mainly to play a local anti-inflammatory role in relieving itching, long-term use may cause skin atrophy, hyperpigmentation and other adverse reactions. The use of this product is prohibited for those who have broken skin and are allergic to this product. All of the above drugs need to be used under the guidance of a doctor, perianal fissure should be timely consultation, to identify the cause of the active treatment of the cause, at the same time should keep the perianal area clean, avoid scratching the affected area, so as not to cause adverse effects.