Antipyretic and analgesic drugs mainly include aspirin, indomethacin and acetaminophen, etc. Which is the preferred drug needs to be decided according to the patient’s condition, and it is recommended that the patient should seek medical treatment as soon as possible and choose the drug under the guidance of the doctor for treatment. 1. Aspirin: Aspirin is a very old antipyretic and analgesic, now mainly used for the prevention of thrombosis-type disorders, its dilation of blood vessels can be achieved through the role of headache relief, the effect of dull pain than sharp pain. 2. Indomethacin: Indomethacin has a better effect on antipyretic and analgesic, especially on inflammatory pain. It is often used to treat acute and chronic arthritis, bursitis, tenosynovitis and arthrogryposis; in addition, indomethacin also has the effect of preventing thrombosis, but the effect is not as good as aspirin. 3. Acetaminophen: Acetaminophen also has good antipyretic and analgesic effects, and has good therapeutic effects on common cold and fever and joint neuralgia, etc. Acetaminophen can also be used for the treatment of cancer pain, with the advantages of fast oral absorption and even distribution in the body.