Breathlessness caused by high total cholesterol and low-density cholesterol is mostly considered to be caused by problems in the coronary arteries of the heart, and patients need to take medication and surgery. High total cholesterol and low-density cholesterol are mostly considered to be hyperlipidemia, if patients with long-term hyperlipidemia is easy to induce atherosclerosis, if the atherosclerosis is the part of the heart, the patient may have chest tightness, shortness of breath, dizziness, chest pain and other manifestations, so the patient will have the symptom of breath-holding. For breath holding caused by hyperlipidemia need to use statin lipid regulating drugs such as simvastatin, avastatin, and cholesterol lowering drugs such as probucol, ezetimibe, etc. under the guidance of the doctor. Patients with severe coronary atherosclerosis can be treated with balloon dilatation, stenting, and coronary artery bypass grafting. It is recommended that patients with high total cholesterol and LDL cholesterol need to consult a doctor in time, who will determine the location of the lesion and choose the appropriate measures for treatment.