There is no so-called “chronic eczema special medicine”. Chronic eczema can be manifested as the affected area of skin hypertrophy, roughness and moss-like rash phenomenon, its treatment drugs are mainly divided into topical drugs and oral drugs, stubborn, serious cases can choose biological agent treatment. 1. Topical drugs Glucocorticoid: according to the site of onset, the degree of disease, choose hydrocortisone ointment, halometasone cream and other drugs for anti-inflammatory treatment. Topical immunomodulators: such as the commonly used tacrolimus cream, pimecrolimus cream, etc., can play a role in relieving the rash, and some patients are susceptible to adverse reactions such as itching, sweating, and hirsutism during the use of these drugs. 2. Oral medications Antihistamines: these drugs can play the role of anti-itch and anti-inflammatory, commonly used drugs such as loratadine, cetirizine, etc., but it is easy to cause drowsiness, dry mouth and other side effects, so avoid driving during the drug period, such as working at heights. Glucocorticoids: such as commonly used dexamethasone, prednisone, etc., suitable for acute inflammation as well as generalized serious patients, can play a rapid control of inflammation can stop itching effect. It is limited to short-term treatment, long-term use may lead to full moon face, buffalo back, skin bruising, osteoporosis and other adverse reactions. 3. Biological agents: such as Duplizumab, is an emerging treatment, can effectively treat eczema. The use of the above drugs should be used under the guidance of a doctor to avoid blind use of drugs. It is recommended that patients with chronic eczema go to the hospital in time and follow the doctor’s instructions.