Urine protein 1+ may firstly be caused by physiological factors such as strenuous exercise and tension, which need no treatment. Secondly, it may also be caused by acute glomerulonephritis, pyelonephritis, chronic glomerulonephritis, etc., which needs to be treated with medication (such as amoxicillin, cefixime, prednisone, etc.). 1. Physiological factors: patients with long-term strenuous exercise or mental overstress may lead to temporary proteinuria, patients with urine protein qualitative examination will appear urine protein 1 +. Generally, no treatment is needed, just pay attention to rest and regular review. 2. Acute glomerulonephritis: acute glomerulonephritis leads to urine protein 1+, need to use penicillin, amoxicillin and other antibiotics under the guidance of the doctor. For patients with acute renal failure, dialysis treatment is also needed to improve symptoms. 3. Pyelonephritis: For pyelonephritis resulting in urinary protein 1+, cefixime, cefuroxime and other antibiotics can be used as prescribed by the doctor. For patients with recurrent urinary tract infections, it is necessary to check whether there is urinary tract obstruction, and if the patient has urinary tract obstruction, it is necessary to be treated by surgery. 4. Chronic glomerulonephritis: can also cause urinary protein 1 +, accompanied by hematuria, hypertension, limb swelling and other conditions, this time the use of valsartan, prednisone and other drugs as prescribed by the doctor. Patients with urinary protein 1 + may also be lupus nephritis, purpura nephritis and other diseases, it is recommended that patients should be timely regular hospitals, under the guidance of the physician to improve the relevant examination, to clarify the cause of the disease, targeted treatment.