Empty big toe nails can be associated with trauma, onychomycosis and perinail warts. 1. Trauma: If the big toe is damaged, the nail bed may be separated from the nail plate, resulting in an empty big toe nail. 2. ringworm of the nail: patients with ringworm of the nail will appear discoloration, thickening, and separation, warping and so on, the onset of ringworm of the nail and ringworm of the skin bacteria infected with the deck, nail trauma, ringworm of the foot, immune impaired and other factors may be triggered by the disease. 3. periungual warts: periungual warts patients’ periungual or nail bed, under the nail may appear hyperkeratosis, papules, plaques and so on, if the warts are large will also trigger the nail deformation, the nail is missing, etc., and the cause of its HPV infection nail plate is related to. The cause of the big toe nails empty is not a reason, it is recommended that the patient to go to the regular hospital to clarify the cause of the disease.