The principles of treatment of sodium bicarbonate extravasation, when the sodium bicarbonate is administered, must be terminated immediately if extravasation is encountered. It is necessary to immediately remove the intravenous infusion channel and give local disinfection, which should be done by wiping and disinfection with iodophor and double water. Because sodium bicarbonate is an alkaline substance, a weakly acidic magnesium sulfate can be applied as a local wet compress and topical compress, which can significantly reduce the swelling and local edema, and also relieve the local redness, heat and pain and vascular erosion caused by sodium bicarbonate extravasation. Potatoes can also be sliced after being cooked and then applied locally to treat sodium bicarbonate extravasation.