The prognosis of focal segmental glomerulosclerosis is poor overall, but comorbidities and pathologic types also have some influence on the prognosis. If there is no hypertension, renal insufficiency, less proteinuria, tip type has a better prognosis, and even some patients can have spontaneous remission. For patients with combined hypertension, proteinuria, renal insufficiency, cellular type and collapsed type, the prognosis is worse. 1. Good prognosis: If there is no obvious hypertension and renal insufficiency symptoms, the amount of urinary protein is low, and the pathological type is the tip type, patients can choose small-dose hormone combined with immunosuppressant treatment, such as prednisone acetate, cyclophosphamide, and tacrolimus; they also need to receive anticoagulant treatment, such as rivaroxaban and warfarin, and regular review, and the prognosis is generally good. 2. Poor prognosis: if combined with hypertension, renal insufficiency, large amount of proteinuria, the pathology is cellular and collapsed type, it is more difficult to cure, generally less sensitive to hormones and immunosuppressants, the goal of treatment is to delay the aggravation of renal function damage, reasonable control of blood pressure, once caused by renal failure, developing into uremia, generally need to carry out renal replacement therapy. It is recommended that patients with focal segmental glomerulosclerosis should go to regular hospitals and receive standardized treatment under the guidance of specialists to avoid delaying their condition.