It is not scientific to say that two classes of drugs are preferred for lowering fasting blood sugar. Fasting blood glucose may choose biguanide as well as long-acting insulin, but other hypoglycemic drugs, such as insulin secretagogues, thiazolidinediones and so on can also reduce fasting blood glucose. 1. Metformin drugs: the most common is metformin, metformin drugs are mainly through the reduction of insulin resistance, promote the uptake and utilization of glucose in peripheral tissues, delay the absorption of glucose by the gastrointestinal tract and reduce blood glucose, reduce fasting blood glucose effect is good, but also have the effect of lowering postprandial blood glucose. 2. Long-acting insulin: Long-acting insulin is usually injected at night before going to bed, and the effect of lowering glucose can usually be maintained for more than 12 hours. The concentration of long-acting insulin in the blood is more stable after the injection, which can control blood sugar for a long time, and the risk of hypoglycemia is relatively low, and it can control the fasting blood sugar well. If the patient’s blood sugar is high, he/she needs to go to the endocrinology department in time and use glucose-lowering drugs correctly according to the doctor’s advice.