Strictly speaking, the level of “transaminase” hardly reflects the function of the liver, as transaminase is just a component of the liver cells, which is relatively high in comparison. At this point in time, if there are not many damaged liver cells, the liver is perfectly capable of working normally. Again, we can use the term “processing plant” to illustrate this problem, in order to maintain the survival of normal people, or normal life activities, about 1/3 of the liver “work” can be, just like some factories, the production capacity is greater than the market demand, part of the workers or In some factories, the production capacity is greater than the market demand, so some workers or some machines stop working will not affect the normal operation of the production line. However, there is a bit of a learning curve on how to properly recognize transaminases. We say that the level of aminotransferases does not fully represent the liver function, but rather the level of aminotransferases does not have a parallel relationship with the liver function status. In summary, there are several situations: 1. normal transaminase level, liver damage persists. This is seen in some hepatitis patients, such as the so-called chronic hepatitis B virus carriers, who have been positive for hepatitis B virus, but the transaminases have never been elevated, but if such patients do a liver biopsy, it can be found that the inflammatory response of the liver is very serious, and some have already undergone fibrosis, and even cirrhosis and liver cancer; there are also many patients with acute and chronic hepatitis C have a similar situation. 2. The transaminase level is very high, but it is only a temporary liver damage, which will not cause a great impact on liver function and the consequences are not very serious, such as taking some kind of drugs that are more toxic to the liver. Our hospital once had an old professor, sick during hospitalization, because of taking a drug, transaminases rose to more than 2000 units, two days after stopping the drug back to normal; In addition, most patients with acute hepatitis A in the onset of the transaminase level is very high, after a short rest and treatment quickly back to normal; a one-time large amount of alcohol will also have a similar phenomenon. 3, jaundice is very deep, transaminases are not high, or even normal. There are three cases: one is bile duct obstruction, poor bile excretion, and when doing liver function test examination, it is found that blood bilirubin is very high, while transaminases are not high or mildly elevated, which can be seen in patients with bile duct stones, tumors around the bile duct and pancreatic head; the second is heavy hepatitis. This is a very serious liver disease with a high mortality rate. In the early stage of the disease, transaminases have different degrees of elevation, bilirubin at a higher level, but as the disease progresses, bilirubin is getting higher and higher, but transaminases fall, and to normal, medically called ” bile enzyme separation “, this is a signal of serious disease, relying on drug treatment is afraid to be of no help, when conditions allow, it is best to do timely It is best to have a liver transplant when conditions permit. In the past two years, our hospital has handled more than a dozen cases of such patients, including a family of three brothers with severe liver disease, after liver transplantation recovered very well. The third is biliary hepatitis. It can be caused by a variety of reasons, mainly damage to the small intrahepatic bile ducts, resulting in abnormal bile secretion, such as various minority acute jaundice hepatitis, drug-related hepatitis, pregnancy, etc. 4. Certain patients with cirrhosis and hepatocellular carcinoma have normal transaminases despite having advanced liver disease and poor liver function. Many people learn about the primary disease only because they have a lot of ascites, gastrointestinal bleeding, or other abnormalities are found during physical examination. It should be reminded that these so-called ” few ” patients are not rare in the case records of our doctors. Today, with the general improvement of people’s living standards, it is indispensable to have one to two health checkups per year to detect many diseases with very insidious onset and slow progress, and cryptogenic cirrhosis is one of them. 5, transaminases long-term abnormal, but the level is not high. This is mostly seen in patients with chronic hepatitis, including chronic hepatitis B and C, autoimmune hepatitis, and alcoholic hepatitis after long-term heavy alcohol consumption. Patients with chronic hepatitis whose transaminase levels are not very high, mostly between 100 and 200 units, or less than 100 units, need the most attention, because this group of patients has the largest number of patients, the disease continues to develop, and the prognosis is the worst, eventually to develop into cirrhosis or liver cancer. It is advisable to take appropriate treatment early, especially antiviral treatment for patients with viral hepatitis. 6, finally there is a class of modern civilization disease, namely fatty liver, manifested as a mild increase in transaminases, generally not more than 100 units, such people are generally overweight, or seriously overweight. In recent years in our country, the incidence of “fatty liver” has been increasing year by year, which is related to improper diet structure, excessive diet, excessive alcohol consumption, lack of exercise, etc. It is a typical “rich man’s disease”. In the past, people called tuberculosis “rich people’s disease”, meaning that only rich people can afford to have the disease, which is really an irony. In modern times, the increasing incidence of fatty liver, hypertension, diabetes, coronary heart disease and cholelithiasis are the real diseases of the rich, and it is time for us to be alert! There is another issue of the name “transaminase” that is worth mentioning. In the general public, the terms “transaminase, GPT, PT, large PT, small PT” are used confusingly. There are two types of aminotransferases, namely “alanyl aminotransferase” and “menthyl aminotransferase”, which are referred to as aminotransferases in medical science. In the past, the letters GPT and GOT were used for short, but now they are called ALT and AST. The liver function test sheets of various hospitals indicate these two types of transaminases, which are enzymes in liver cells.