GnRH-a has no effect on breast nodules. GnRH-a refers to the use of gonadotropin-releasing hormone agonists to treat a variety of obstetrics and gynecology conditions. GnRH-a treatment is the use of gonadotropin-releasing hormone agonists, which are synthetic drugs, to effectively control the treatment of diseases. Indications include endometriosis, uterine fibroids, precocious puberty, and premature ovarian failure. In addition, GnRH-a treatment also has an assisted reproductive role, improving the quality of eggs and increasing the chances of conception by synchronizing follicular development. GnRH-a treatment also has certain side effects, there will be hot flashes (a burst of fever), vaginal dryness, loss of libido and osteoporosis and other menopausal symptoms, which can disappear after stopping the medication, and there is no aggravation of breast nodules. It is recommended that patients go to regular and timely hospitals to play GnRH-a, improve the relevant examination, and actively cooperate with professional doctors for follow-up treatment.