What are the chances of confirming a diagnosis of trisomy 21 depends on the type of test chosen, for example, Down syndrome is 60% to 70% accurate, non-invasive DNA is up to 99% accurate, and amniocentesis is 100% accurate. Down’s syndrome screening is between 60% and 70% accurate. It is based on a woman’s weeks of pregnancy, height, age, weight and blood combined to go for a risk assessment, and the results can be affected by incorrect weeks of pregnancy at the time of testing. A child born at high risk from Down’s syndrome screening may not necessarily have Down’s syndrome and will require further non-invasive DNA. The accuracy of non-invasive DNA is higher than that of Down’s syndrome screening. The accuracy of non-invasive DNA testing for trisomy 21 can reach 99%. Non-invasive DNA suggests that trisomy 21 is a high risk, which means that there is a high probability that the fetus will have the disease, but there are still a small number of exceptions, so further amniocentesis is required to accurately determine this. Amniocentesis has a 100% accuracy rate. The amniotic fluid is extracted directly and centrifuged to obtain fetal exfoliated cells, which are then cultured to determine whether the fetus has Down syndrome. It is recommended to have a good pregnancy checkup to be able to determine whether the fetus has Trisomy 21 or not.