Today, I consulted a patient in his department, who was considered to be a peripheral lung cancer with intrapulmonary metastasis according to the examination. I suggested the patient and his family to perform lung puncture and get the pathology to determine the treatment plan. The patient and his family were very confused and said, “We said it is cancer, so we should treat it, why do we need to puncture it? This is the question of many patients and their family members, and we are here to answer this question today. Zhang Hongliang, Department of Oncology, Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine In the treatment of tumor, there is a principle that “there is no treatment without diagnosis”, and the diagnosis here is strictly pathological diagnosis, that is, the tumor tissues removed through endoscopy, puncture, surgery, etc. are “identified” through microscope. “The lung cancer I mentioned earlier should be broadly divided into small cell lung cancer, adenocarcinoma and squamous carcinoma, and the treatment plans for different subtypes are very different and the prognosis is also different. With the development of tumor treatment, the genotyping of tumors is becoming more and more detailed, and the treatment options for different genotypes are different. Currently we commonly use erlotinib, gefitinib and erlotinib which are effective for lung cancer patients with EGFR gene mutation and not for other patients. Therefore, clarifying the diagnosis is necessary to choose the right treatment, and it is also a guarantee to improve the efficiency of treatment to avoid spending money. Secondly, I would like to tell you about percutaneous puncture. For this patient’s lung tumor near the chest wall, percutaneous lung puncture is the best choice. First of all, it is not painful for the patient, the whole process is just like playing muscle needle, definitely not as painful as bronchoscopy; secondly, it is less traumatic, the wound is the eye of the needle, only a band-aid is needed after puncture. Regarding the spread of the disease after puncture, as long as the patient actively cooperates with the treatment after puncture, the chance of spreading along the needle tract under effective treatment is very low. Our department has been carrying out minimally invasive diagnostic techniques such as breast puncture, thyroid puncture, percutaneous lung puncture, percutaneous liver puncture, percutaneous abdominal mass puncture and pleural biopsy for a long time, and we have not found a single case of spread along the needle tract, so such worries are unnecessary. We hope that we can establish the correct concept and not to miss the “best solution” of tumor treatment.