If pustules appear on the arms of newborns after vaccination, most of them are due to normal physiological reactions. Because of the immune reaction after vaccination, especially after BCG vaccination, most newborns will have pustules on their arms and will have the sequelae of card scars, mainly due to the normal effect of the vaccine. In this case, if the pustules on the arm are not particularly serious, parents do not need to treat them and most of them will heal themselves. If the pustules on the arm are very heavy, they should be treated with topical antibiotics, such as Bactrim or rifampin or isoniazid. Especially for post BCG vaccination reactions in newborns, isoniazid and rifampicin should be applied to achieve good results.