For the phenomenon of acne at the corner of the mouth, it usually belongs to the chronic inflammation of the sebaceous gland area of the hair follicle, and it is considered to be related to microbial infections, androgen increase, etc. It can be removed by topical medication, oral medication, and other treatments. 1. Topical medication: patients can use topical adapalene gel, benzoyl peroxide ointment, etc., which can help dissolve and expel acne. If it is related to microbial infection, it can be co-treated with topical clindamycin and fusidic acid cream application. 2. Oral medication: If acne occurs repeatedly, oral isotretinoin or anti-androgenic drugs such as cyproterone can be combined. 3. Other treatments: Patients can combine red and blue light irradiation to inhibit sebum secretion and destroy Propionibacterium acnes through optical effects, improving symptoms. It is recommended to treat under the guidance of a doctor, do not blindly use drugs to avoid adverse effects. The above medications should be used in accordance with medical advice.