Lupus erythematosus generally refers to systemic lupus erythematosus (SLE). Positive anti-Sm and anti-double-stranded DNA antibodies can provide an important basis for the diagnosis of SLE, but anti-Sm and anti-double-stranded DNA antibody positivity alone cannot confirm the diagnosis of SLE.
SLE is a connective tissue disease, and the hallmark autoantibodies mainly include anti-double-stranded DNA antibody, anti-Sm antibody and anti-rRNP antibody, of which anti-double-stranded DNA antibody is related to the activity of SLE, and the positivity of anti-Sm antibody and anti-double-stranded DNA antibody occupies a relatively high weight in the diagnostic criteria of SLE.
In addition to autoantibody test, the diagnostic criteria of SLE also include patients’ skin symptoms, joint symptoms, kidney biopsy, proteinuria, complement, etc. It is necessary to further confirm the diagnosis of SLE by comprehensively analyzing whether the patient meets the diagnostic classification criteria of SLE.
SLE patients can go to the rheumatology and immunology departments of regular hospitals for detailed consultation.