Positive antisperm antibodies are found in men on the one hand and in women on the other. In men, anti-sperm antibodies are usually found in the semen or blood of men and are diagnosed by a positive test of semen and blood for anti-sperm antibodies. If a man is positive for antisperm antibodies, it usually results in low quality and low viability of sperm in semen, which can lead to low fertility rates and infertility. In women, anti-sperm antibodies are usually found in the blood, and the diagnosis is confirmed by a positive blood test for anti-sperm antibodies. Positive anti-sperm antibodies in women also have an impact on the conception rate and can easily cause infertility in women because the sperm entering a woman’s body can cause low quality semen, low conception rate and poor vitality due to the effect of anti-sperm antibodies. In general, the treatment for anti-sperm antibody positivity is to remove the impurity components, especially allergenic components, from the semen by processing, washing and centrifugation, and the pure semen is injected into the female vagina or uterine cavity through artificial insemination and assisted reproduction techniques to assist conception, which can greatly improve the conception rate. Therefore, the treatment of infertility is also the treatment of anti-sperm antibody positivity.