During puberty, the feedback regulation between the hormones of the hypothalamic-pituitary-ovarian axis is not yet mature, resulting in the inability of the ovaries to ovulate. This anovulation can lead to continuous proliferation of the endometrium under the stimulation of a single estrogen without progesterone counteracting and estrogen breakthrough bleeding, the most common symptom being irregular uterine bleeding, characterized by disrupted menstrual cycles, variable length of periods, variable menstrual volume, and even heavy bleeding. Treatment: 1. General treatment of anemia should be supplemented with iron, vitamin C and protein, blood transfusion is needed for severe anemia, and antibiotics are given to prevent infection in cases of prolonged bleeding. 2. Medication, often using sex hormones to stop bleeding and adjust the menstrual cycle, can be taken orally with compound short-acting oral contraceptives to stop bleeding, and after stopping bleeding the menstrual cycle must be adjusted to restore normal endocrine function in order to establish a normal menstrual cycle, which can be done artificially cycle or combined estrogen and progestin method.