The rough mucosa of the cardia is not necessarily cancer. The cardia is located between the esophagus and the stomach, and the muscles around it are more developed to inhibit food reflux in the stomach. The roughness of the cardia mucosa found during the examination indicates that there is irregular hyperplasia of the mucosa in the cardia area, and this condition is related to mucosal inflammation, ulcers, and cancer, so there is a certain possibility that it is caused by cancer. For those who find roughness in the mucosa of the cardia, it is best to take a biopsy from the suspected area and perform pathological examination to determine if it is caused by cancer. Once the presence of cancer cells is detected during the examination, it indicates that cancer must have occurred and should be treated as soon as possible. For patients who do not have cancer cells, they should be treated with drugs that promote mucosal repair and inhibit gastric acid secretion. In addition, liquid or semi-liquid food should be used during the treatment period to avoid damaging the mucosa of cardia and affecting the treatment of the disease.