Post-exposure injections of rabies vaccine are generally given using the five-shot method, with the fourth shot given on the fourteenth day, one day later, which means that the fourth shot is changed to the fifteenth day. If only this one-day change is made in the five-dose method, it is possible that the amount of rabies-neutralizing antibodies produced, as well as the duration, will have no particular effect. However, it is also not recommended that the fourth injection be given one day later for no reason, as there is really no information to determine that a fourth injection given one day later will result in a larger change in the amount of rabies antibodies compared to the normal five-shot method procedure, which is generally considered to be a relatively small change. Therefore, it is not recommended to give the fourth shot late for no reason at all, but if there are circumstances that prevent the fourth shot from being given at the required time, it is actually possible to give it a day late.