Acute rash is the short name for infantile acute rash, which is a viral infection followed by a rash. It usually occurs only once in a child’s body with immunity, and the second occurrence may be caused by different viral infections, such as human herpesvirus type 7, adenovirus, and echovirus. Acute infantile rash is common in children between 6 months of age and 1.5 years of age, and is most commonly caused by human herpesvirus type 6 infection. Symptoms include high fever for 3 to 5 days, and after the fever subsides, a rash on the trunk, face, hands and feet, which fades completely in 1 to 2 days without hyperpigmentation or desquamation. If a child has 2 episodes of fever and rash, it is important to consider the presence of different viral infections, such as human herpesvirus 7, adenovirus, echovirus, etc. It is also important to differentiate it from rubella, measles, and allergies. Young children do not usually get acute rash twice. If fever and rash occur again, consult a specialized pediatrician to avoid misdiagnosis of other rash diseases.