When the examination found HPV53 positive, and the vulva and vagina appear polypoid fatty organisms, consider related to condyloma acuminatum, may cause vaginal burning sensation. Warts is due to human papilloma virus infection caused by sexually transmitted diseases, the patient onset of more red particles, with the progress of the disease, the local manifestation of the cauliflower pattern or polypoid liabilities, the surface is prone to erosion, ulceration, or bleeding, so that the patient can be manifested in the vulva, the vagina, the local burning feeling of discomfort. Currently, this disease is mostly treated by imiquimod cream, and if necessary, through laser, freezing and other physical therapy to remove the local warts, so as to play a role in the treatment. For women who are found to be HPV53 positive and have polypoid warts on the vulva and vagina, it is recommended that they go to the gynecology department of a regular hospital as soon as possible to get a clear picture of the cause of the disease and then actively treat it under the guidance of the doctor.