Pentavalent vaccine can be given if the cough is caused by physiological factors. If the cough is accompanied by symptoms such as fatigue and depression, the administration of Pentavalent vaccine may increase the risk of serious reactions to the immunization, cause confusion in diagnosis, or impair the immunity efficacy of the vaccine. Pentavalent vaccine protects against polio, whooping cough, diphtheria, tetanus, and Hib pneumonia at the same time. If the cough is physiologic and normal, such as when the throat is irritated by smoke or after choking on food, then the Pentavalent vaccine can be given. If the cough is severe and accompanied by symptoms such as fatigue and depression, it is not acceptable to receive DPT5 vaccine because if you are taking medication to treat cough symptoms, receiving DPT5 vaccine may cause adverse reactions, increase the risk of serious reactions to immunization, cause diagnostic confusion, or impair the efficacy of vaccine immunization. Therefore, it is important to note that patients who have an allergic reaction to any of the components of the DPT vaccine are not suitable for vaccination, and vaccination should be postponed during cough or acute illness. If any adverse reaction occurs, it is necessary to go to the hospital in time for detailed examination and standardized treatment under the guidance of the doctor.