Why do liver cells “turn bad” into cancer? And these 3 bad habits are inseparable!

I am a hepatocyte

Hepatocyte factory employee #8102, or bricklayer for short

Every day, I have a long list of jobs to do:

Filtering the sewage, toxins and waste from the blood vessels

Preparing bile and processing clotting factors according to secret recipes

Packing and storing liver glycogen and protein in storage

…… 

When I’m short-handed, I split

As one gentleman said:

One liver cell goes down

There are millions of other liver cells standing up

I work strictly on a 24-hour basis

We don’t take a vacation until the earth explodes

Finally, in my 18th year on the job

I was awarded the five-star model worker in the factory

Finally, I was physically exhausted the night before I received the award

Fell on the workstation ……

 When I woke up, I suddenly felt a chill in my back

 It turns out that there are a few new strange guys in the factory

 were eyeing me up

Hepatitis B oldest brother was the first to approach me

Since knowing that the tablet immune cells hadn’t seen the hepatitis B vaccine 

He came to my house twice a day to play games all night

Finally, he just stuck around

Stealing my instant noodles and swiping my credit card to buy equipment

It’s a shame I trusted him too much

They have been unaware of it for years

In contrast, the alcoholic brother is much more generous

I was often invited to have a drink and talk about life

Every time I get drunk, I’m red-faced

I accidentally told the truth

 I don’t know why, but every time I drink it, I lose something

but I’m slowly getting addicted to drinking

The big sister of aflatoxin is the owner of the miscellaneous food store downstairs

Once there is unsold melon seeds peanuts eight porridge

She is always the first to think of me

I can’t help but sigh: there are still many good people in the world

Although there is always diarrhea after eating

Later on, the elder sister of the yellow tetracycline called me at length:

“With all due respect, there aren’t many kids as silly and white as you these days!

I can’t even bear to keep lying to you!

I gave you two years of spoiled food

After driving out acetaldehyde dehydrogenase

The acetaldehyde that alcohol turns into poisons you

To this day, the hepatitis B virus wreaks havoc in your house

His associates have infiltrated thousands of homes

Once the immune cells find out, none of you will survive!”

Ugh, who told me to save face

I’m extremely self-repairing

After many heavy blows

I’m a brick wall inside

(I didn’t know that this was actually the beginning of cirrhosis) 

Surely choose to forgive them ……

But then suddenly one day I felt out of control

Want to go on strike, want to bounce, want to go out and smash and grab!

Yes, I’ve changed, it’s genetically wrong

When I went out, my brother next door also had a bad smile on his face

Since then we have a new name:

Liver cancer cells!

We worked well together and quickly took over a villa area

As the saying goes

“If you want to be rich, first build a road”

So we got

Vascular endothelial growth factor (VEGF) construction team

Let them build a few new vessels from the main vascular artery

20 minutes straight to the CBD

So you can have takeout delivered from the city

We started ganging up

Inciting more liver cells to join our group

Following these highways, we can also group out

For example, a day trip to “portal vein cancer thrombosis

To see the spectacle of the three rivers converging in the hepatic portal vein;

such as the “metastatic liver cancer” sightseeing tour abroad

Going to live in the alveolar rainforest and the Museum of the Brain for half a month

I’m used to being a hard-working, law-abiding overtime dog

It’s better to be a cancer cell!  

It turns out that you can really do whatever you want with money

But it didn’t last long ……

3 months ago a group of city police

Without a second thought, they issued a ticket

The VEGF construction team was taken away

These are some big city cops:

Sorafenib, old and strong 

Lenvatinib, young and talented

If they can’t get it right

There’s regorafenib,

in the second line

Cabozantinib at their disposal

At the risk of starving to death 

We decided to fight a “guerrilla war” 

Going back in the day

We stopped working during the day and worked late at night

The road was finally fixed before the year was up

Just when we were celebrating at the hotel

There was a siren in the distance

What, the T-cell police brigade?

We never disguise ourselves as “good people” in the city

The  PD-L1 fake IDs are no different from normal cells 

Even the police’s  PD-1  security checker can’t detect the true or false

How come a surprise attack today?

After careful inquiry

There are a group of hackers called Navumab

Technically disabling all PD-1 security cameras!

T cells had to use the most primitive and stupid method:

Take off your clothes and see who has the most tattoos (antigens) on their body

Just! Grab! Who!

Me and a bunch of minions shivering ……

Last words

Fellow still normal liver cells

If you see

Hepatitis B virus, alcohol, and aflatoxin

These three liars 

Just leave them

Also, never try to be on the edge of breaking the law ……

Hepatocellular carcinoma cell #8012