Children who take antipyretic drugs do not reduce fever, can be seen in the disease in the acute stage or critical condition, the use of antipyretic drugs dose is insufficient or observation time is insufficient, the specific treatment needs to be based on the cause of the decision. 1. Disease in the acute stage or critical condition: when the disease is in the acute stage, such as influenza children, the use of antipyretic drugs can be ineffective phenomenon, need to closely observe the children’s mental condition, such as the temperature is in a high fever state and persistent, the need for physicians to re-assess the condition, may be appropriate to use dexamethasone and other treatments. Or in critical illnesses, such as severe pneumonia, sepsis, etc., the above situation can also occur, the child often poor mental response, bacterial infection treatment needs to strengthen the anti-infection efforts. 2. Inadequate use of antipyretic doses: Parents who do not give the appropriate dose of antipyretic medication (e.g., ibuprofen or acetaminophen) based on the child’s weight may experience the above phenomenon, and need to be evaluated by a physician who specializes in the treatment of antipyretic medications at the appropriate dosage. 3. Insufficient observation time: It is usually believed that the temperature of febrile children gradually decreases in about 30 minutes after the use of antipyretic drugs, and the temperature of some children may gradually decrease in 2~3 hours, which is related to the condition of the child and other factors have to be observed, and this kind of children may be subjected to physical hypothermia such as warm water wiping and close monitoring of the temperature and observation of the spirit and so on. It is recommended to consult a physician for evaluation and reasonable intervention by a specialist. The above medications should be used under the guidance of a physician, avoid self-medication.